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Author Contributions Concept and design: Ravi Teja Kolli, Sridevi Aoutla, Nirmal Jyothi, Mohamed Raghib Hussain Mohamed Kalifa, Kavya Cheenikkal Muralidharan Acquisition, analysis, or interpretation of data: Ravi Teja Kolli, Arvin Raju Drafting of the manuscript: Ravi Teja Kolli, Sridevi Aoutla, Nirmal Jyothi, Mohamed Raghib Hussain Mohamed Kalifa, Arvin Raju Supervision: Ravi Teja Kolli Critical review of the manuscript for important intellectual content: Sridevi Aoutla, Nirmal Jyothi, Kavya Cheenikkal Muralidharan References 1.The epidemiology of obesity: a big picture

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Weight Loss Distribution The results weren't just impressive on averagethey were consistent across the patient population: Weight Loss Thresholds Achieved (12mg dose): 5% weight loss: 94.6% of participants 10% weight loss: 91.3% of participants 15% weight loss: 83.2% of participants 20% weight loss: 73.4% of participants 25% weight loss: 58.6% of participants For comparison, FDA approval for obesity medications typically requires that at least 35% of patients achieve 5% weight loss

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CAS Number 2381089-83-2 Molecular Weight 4731.33 Da Molecular Formula CHNO Class GIP/GLP-1/Glucagon Triple Receptor Agonist Research context

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Constipation may respond to increased fiber intake, adequate hydration, and physical activity, with stool softeners or gentle laxatives if needed

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