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DNA replication stress as a hallmark of cancer

As a result, the balance between cell proliferation and apoptosis is disrupted, contributing to gastric carcinogenesis ( waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Figure 3)

Hruby received a number of academic awards for work in this area

Combination Therapies: Investigating BPC-157 in combination with other established therapies (e.g., physical therapy, other regenerative treatments like PRP, or conventional medications) could reveal synergistic benefits and optimize patient outcomes