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Description

Distinct roles for the hypoxia-inducible transcription factors HIF-1 and HIF-2 in human osteoclast formation and function

Relative contraindications such as significant kidney impairment or active gastrointestinal disease call for closer monitoring or specialist input instead

Nature 620 , 890897 (2023)

To test this possibility, we performed cgMD simulations of GLP-1R in active versus inactive conformations in a model mammalian plasma membrane using the latest Martini 3 forcefield and cholesterol parameters, identifying specific receptor sites with high cholesterol occupancies and residence times