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Higher levels of ROS within myofibers trigger pathophysiological signaling and induce apoptosis and proteolysis [137, 138]

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The ER also communicates with mitochondria via signaling from the unfolded protein response (UPR), which is activated by ER stress and signals through the three ER-resident stress sensors IRE1, PERK, and ATF6 (Walter & Ron, 2011)

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These include: Type 2 Diabetes management: Both medications can help improve blood glucose control in individuals with type 2 diabetes by stimulating insulin production, inhibiting glucagon release, and slowing down gastric emptying Cardiovascular improvement: Saxenda and Ozempic may help reduce the risk of cardiovascular events such as heart attack and stroke in individuals with type 2 diabetes and heart disease Polycystic Ovary Syndrome (PCOS): Weight loss achieved with Saxenda or Ozempic may have a positive impact on PCOS symptoms, although further research is needed in this area Section 7: Saxenda vs