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The ratios of starting materials and the calculated TON and TOF in the reactions

ADCs have also shown emerging therapeutic potential in the treatment of autoimmune diseases

However, it's important to contextualize this assessment within the limitations of the available evidence: most safety data comes from relatively small studies, often of short-to-moderate duration, conducted primarily in the Soviet Union, Russia, and Eastern Europe where methodological standards and reporting practices have sometimes differed from Western pharmaceutical trial requirements

Biomaterials, 2019, 188: 8395 Zhang G, Cheng W, Du L, et al

Singh H, Du J, Singh P, Yi TH