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Inappropriate usesuch as unapproved products or administration by unqualified individualscan increase the risk of complications

Certainly, human patients with T2DM display a blunted incretin effect of GLP-1, and defects in meal-induced intestinal GLP-1 secretion (91), suggesting that the paracrine action of alpha-cell-derived GLP-1 may be necessary to combat this diminished peripheral incretin action of gut-derived GLP-1

doi: 10.1016/0306-4530(88)90021-2 21 WeitzmanEDNogeireCPerlowMFukushimaDSassinJMcGregorPet al

We separated nuclear and cytoplasmic proteins and calculated the ratio of p-P53 to total P53 in each fraction

[DOI] [PubMed] [Google Scholar] 59.Antoniades C., Shirodaria C., Warrick N., Cai S., de Bono J., Lee J., Leeson P., Neubauer S., Ratnatunga C., Pillai R., et al