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78 A statistical analysis that included nine randomized controlled trials, involving a total of 591 women with PCOS, also reported finding omega-3 fatty acid supplementation improved insulin sensitivity, lowered total cholesterol and triglyceride levels, and raised levels of adiponectin (a signaling peptide primarily produced by fat tissue that improves insulin sensitivity and has anti-inflammatory properties)
Furthermore, DPP-4i could inhibit the expression of MCP-1 in mouse proximal TECs upon free fatty acid binding to albumin and significantly attenuate renal tubulointerstitial injury ( 4.4 Glucagon-like peptide-1/GLP-1 receptor agonists Endogenous and pharmacological activation of the GLP-1 receptor (GLP-1R) axis is thought to be reno-protective in DM (189)
J Neuropsychiatry Clin Neurosci
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