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It is assumed that the additional loss of tumor suppressors such as PTEN (phosphatase and tensin homolog) and CDKN2A (cyclin-dependent kinase inhibitor 2A) leads to a progression from naevi to melanomas by entering the radial growth phase (RGP) [12]

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In vitro pharmacology (EC 50 ) Evaluation of the agonist activity of compounds 1 23 at the mouse GLP-1 receptor endogenously expressed in TC6 cells, was determined by measuring their effects on cAMP production using the HTRF detection method (performed by Cerep S.A., catalogue 2015, ref