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The OGD and erastin treatments inhibited the activity of the antioxidant system by downregulating the activation of the SLC7A11/GPX4 axis
Furthermore, the PfGrx-catalyzed oxidation of roGFP2 is more than four orders of magnitude faster than the uncatalyzed reaction with GSSG and occurs two orders of magnitude faster via the glutathione-dependent monothiol mechanism than by the glutathione-independent dithiol mechanism (Fig
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[10] [12] It may reduce the efficacy of certain anticoagulants, such as warfarin, by affecting hepatic metabolism or interfering with laboratory monitoring of coagulation parameters
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