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The trial also met the dual primary endpoint of proportion of participants achieving at least 5% weight loss at 26 weeks, with up to 88.8% of participants receiving elecoglipron achieving this threshold

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This pharmacological profile makes it uniquely well-suited as the GHS-R1a component of a dual-receptor combination, adding acute calcium-dependent GH vesicle release without the adrenal or gonadal axis interference that complicates use of other GHRPs