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Additionally, "some herbal or 'natural' remedies for constipation, like aloe, cascara, or senna-based products are stimulant-based," says Hamilton, "meaning they work by causing the intestines to contract more forcefully." While these supplements can be effective for short-term relief, Hamilton warns that frequent use can lead to cramping, diarrhea, or dependence

The findings, published in Nature Medicine , reveal these medications affect far more bodily systems than previously recognized

Drugs metabolized by CYP3A (certain statins, blood thinners, antiarrhythmics, immunosuppressants, migraine medications, antidepressants) may interact

However Lillys demonstration that a GIP/GLP-1 receptor co-agonist (tirzepatide) has superior efficacy compared to selective GLP-1 receptor agonists, has renewed interest in the first incretin. Lilly rolled out their SURPASS trials to position their agent amongst existing diabetes medications and GLP-1 agonists

Check the expiration date on the label