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This page focuses specifically on how undermethylation in autism may affect SAM, creatine production, transsulfuration, glutathione protection and mitochondrial energy

G1, G2 and G3 showed onefold, 1.3 fold and 1.1 fold increase in activity of APX as compared to control

It is produced naturally in the body

At physiological levels ROS modulate cell cycle and proliferation, activate angiogenesis, enable phagocytosis, activate antioxidant genes and pro-inflammatory cytokines [22, 24, 26, 27]

For H 2 O 2 treatment, 100 M H 2 O 2 was added to RPMI 1640 growth medium (#1003461059, Sigma Aldrich, United Kingdom), without FBS and phenol red, supplemented with 15 mM HEPES (#1003098482, Sigma Aldrich, USA), 27.9 mM sodium bicarbonate (#101920550, Sigma Aldrich, Japan), 0.2 mM sodium pyruvate (#1002136564, Sigma Aldrich, Japan), 1 U/mL penicillin, and 1 g/mL streptomycin