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1 Model based estimates based on an analysis of covariance model including randomized treatment as factor and baseline value as a covariate Missing data were multiple imputed from retrieved subjects of the same randomized treatment arm (RD-MI) in Study 8 or all retrieved subjects regardless of treatment arm assignment in Study 9

Schmidt WE, Christiansen JS, Hammer M, Zychma MJ, Buse JB

[7] Lamotrigene: At least six negative trials [18] out of 11 RCTs (N = 948), with moderate confidence in the evidence, but with a small effect size (SMD: 0.16 (0.03-0.29)

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However, if the swollen area grows larger than 2 inches in diameter or doesnt improve after two days, its time to reach out to your doctor