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Lupus nephritis (LN)the most severe SLE manifestationaffects most patients within 5 years of diagnosis, with ~10% progressing to end-stage kidney disease (ESKD) (212)

doi: 10.1016/S0140-6736(18)32261-X 229 GarveyWTFriasJPJastreboffAMle RouxCWSattarNAizenbergDet al

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Only about 17% of patients under 10 years of age are found to have neuropsychiatric symptoms at presentation, whereas in patients presenting after 18 years of age, 74% experience neurologic manifestations.2,20 It is usually after 10 years of age that patients may manifest evidence of involvement of the other organ systems such as renal, hematologic, and endocrine (Figure 252)

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