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Another important detail is that the GIP component may help improve tolerability for some patients compared to older GLP-1 medications alone

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In several cases, durable metabolic benefits appear to require co-administration with specific dietary substrates or prebiotics, such as inulin-based synbiotics or chemically modified resistant starch, highlighting that both microbial composition and nutrient context are critical for colonization stability and functional output (Wang et al., 2025)

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