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A patient with obesity and an increased risk profile may need closer monitoring than someone with a smaller amount of weight to lose, which can affect scheduling and cost
They torch fat and improve mood
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Some studies show that up to 40% of the weight loss observed in patients on semaglutide is attributable to loss of lean muscle mass, which is viewed as a major shortcoming
The original FLOW (Evaluate Renal Function with Semaglutide Once Weekly) trial in 3533 patients with type 2 diabetes and CKD found subcutaneous semaglutide 1 mg once weekly reduced the risk of the primary kidney endpoint (at least a 50% decline of estimated glomerular filtration rate, kidney failure or kidney or cardiovascular death) by 24% and all-cause death by 20%
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