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To observe exo-enzymatic H 2 O 2 disproportionation, it would however be necessary to use immobilised catalase [Yoon et al

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Only the media taken from cells incubated at high temperatures (39.2 O C) was able to induce growth of gsh1 -cells

These observations suggest a significant contribution of CYPOR to NFT-induced Nrf2 activation in the HepG2 model, but also indicate that other cellular flavoprotein reductases are likely to be involved in the formation of the NFT radical anion and its subsequent activation of Nrf2 and synthesis of GCLC and glutathione