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The STEP UP trial in people with obesity tested the higher dose of semaglutide (7.2mg) against the 2.4mg dose and placebo over 72 weeks in over 1,400 adults living with obesity without type 2 diabetes

Because they act through non-overlapping mechanisms, some protocols examine them in combination or parallel though combination research should have a clear mechanistic rationale

Ipamorelin is not FDA-approved and has no approved human indication

It also has reportedly displayed impacts in reducing cardiovascular and kidney disease risks by over 35 percent

For patients paying out of pocket and seeking an alternative to expensive brand-name medications, the convenience may be appealing