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An abundance of copper triggers a reduction process and fosters cell death by encouraging the abnormal oligomerization of copper-dependent, lipoylated proteins in the tricarboxylic acid (TCA) cycle, while simultaneously diminishing the concentration of iron-sulfur cluster proteins

B12 supports brain health and helps regulate mood, which can reduce emotional eating and boost motivation

This step was defined as the rate-determining step experimentally since the activation of the triplet state dioxygen is a spin-forbidden transition, but biological systems (enzymes) can do that

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Rare but serious side effects include pancreatitis, diabetic retinopathy, thyroid tumors, and kidney damage