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Research on transdermal delivery of herbal extracts for metabolic effects is limited

The actual evaluation of cardiovascular benefits will be achieved with the completion of the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial, which enrolled 9,340 T2D patients randomized for treatment with liraglutide or placebo for an estimated period of 5 years (ClinicalTrials.gov Identifier: NCT01179048)

found that inhibiting the GPX4 with RAS-selective lethal small molecule 3 (RSL3) enhances the antitumor effect of cisplatin (Zhang et al., 2020)