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Strzalkowski AK., et al

Research in rat pinealocytes showed that epitalon upregulates two key enzymes in the melatonin synthesis pathway AANAT and pCREB directly stimulating endogenous melatonin production at the cellular level

95% CI, 2.47-13)

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In addition, the composition of multiple constituents of Pycnogenol , each having different benefits for human health, further explains its broad clinical application ( For the first time, this review aims to systematically summarize and discuss these gold standard RDP trials comparing the efficacy of Pycnogenol to placebo and giving explanations for the different effects with the help of the respective mechanisms of action