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It is a leading compound in the removal of hydrogen peroxide, which is toxic in the cell

Several factors cause this variability

Treatment with FGF21 significantly reduced lesion size, decreased brain edema, alleviated apoptosis, and improved neurological outcomes in mice post-TBI

For example, when the growth hormone (GH)/Insulin like growth factor (IGF)-1 axis and insulin resistance were measured after intermittent fasting and caloric restriction over two years in non-diabetic obese subjects, metabolic parameters were positively impacted by caloric restriction, while intermittent fasting (with no caloric restriction) enhanced cellular resistance to disease but without weight loss [56]