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Additionally, LDNs effect on opioid receptors can positively impact mood and alleviate fatigue, creating a holistic improvement in patients quality of life [28,29,30,31,53]

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In addition, other studies indicate that dyspnea, autonomic symptoms, post-traumatic stress and fibromyalgia symptoms (muscle aches, myalgia, and articular pain) are common [109,110,111]

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One important distinction: some early clinical observations noted rare cases of thrombotic events in specific patient subgroups, particularly those with existing clotting disorders or recent surgeries