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72 GLP-1R knockout mice exhibit significantly reduced expression of key genes involved in epithelial protection and repair, including trefoil factor (Tff)1, Tff2, TGF-1, TGF-3, epidermal growth factor receptor (Egfr), keratinocyte growth factor (Fgf7), and hepatocyte growth factor (Hgf), implicating GLP-1R signaling in mucosal healing pathways

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Others simply stop the treatment altogether