It is important to recognize that clinical trials may have limited power to detect small increases in risk for specific rare cancer types, and longer-term observational studies will continue to provide important safety information
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Am J Kidney Dis 71(1):6574 Tonneijck L, Muskiet MHA, Smits MM, van Bommel EJ, Heerspink HJL, van Raalte DH et al (2017) Glomerular hyperfiltration in diabetes: mechanisms, clinical significance, and treatment
Studies in animal models have indicated protective effects against hypertension-induced kidney damage, while clinical trials, such as the LEADER trial, have confirmed the renal and cardiovascular benefits of GLP-1RA, particularly in patients with CKD [89] (Figure 1)
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