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Peptides are essentially chains of amino acids, and heat provides the energy for chemical reactions that can break those chains apart or cause them to fold incorrectly, rendering them useless
Functional activation of DCs stimulates NK-cells, promotes an increase in proinflammatory cytokines (IL-12, IL-6, IL-23, IL-1) and a decrease in antiinflammatory transforming growth factor- (TGF-1), which control adaptive reactions, which contributes development of Th1 and Th17, IL-17-producing T cells and cytotoxic T cells
Further research is still needed to confirm these facts
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