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Research published in neuroscience journals has shown that administration of exenatide, liraglutide, and semaglutide decreases alcohol consumption in alcohol-preferring rats and mice, with effects observed across various experimental paradigms including two-bottle choice tests and operant self-administration models

A retrospective cohort study of electronic health records of 83,825 patients with obesity demonstrated that semaglutide use compared with other anti-obesity medications is associated with a 50%56% lower risk for both the incidence and recurrence of alcohol use disorder [135]

Of note, the CSF1R inhibitor PLX-3397, which depletes myeloid cells, restored cognitive function both in the co-housing setting and after 3-HOA administration (Fig

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