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GLP-1, GIP, and Glucagon Receptors: Understanding Triple Agonism Retatrutide targets three hormonal receptors: GLP-1 (appetite suppression and insulin secretion), GIP (incretin and fat metabolism), and glucagon (energy expenditure and lipolysis)

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GLP-1 receptor agonists and risk for cirrhosis and related complications in patients with metabolic dysfunction-associated steatotic liver disease

Additionally, in vivo assessments demonstrated a reversal of histological changes via downregulation of the NF-B signaling pathway