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Key Takeaways: Semaglutide in Your System Semaglutide has a half-life of approximately 7 days (one week) Takes about 5 weeks after your last dose for complete clearance from your body Reaches steady-state levels after 4 to 5 weeks of consistent weekly dosing Long half-life enables once-weekly dosing instead of daily injections Side effects can persist for several weeks after stopping treatment Weight regain typically begins 4 to 8 weeks after stopping Wait at least 8 to 10 weeks after last dose before trying to conceive Wont show up on standard drug tests for employment or similar screening Understanding Half-Life: What Does It Mean

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