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ROS Overproduction: The Initiating Driver Hyperglycaemia activates multiple simultaneous ROS sources, including mitochondrial uncoupling, NADPH oxidase isoforms NOX2 and NOX4, and xanthine oxidase upregulation

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At last follow up, 20.3% and 23.4% of LTSG patients had steatosis and fibrosis, respectively, versus 40.4% and 37.3% of LT-only patients with steatosis and fibrosis respectively ( p =0.01 steatosis, p =0.12 fibrosis)

Neuromuscular junction impairment in amyotrophic lateral sclerosis: reassessing the role of acetylcholinesterase