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The reality is more nuanced, but also more hopeful than you might expect

While Mounjaro was originally approved for type 2 diabetes, many patients were prescribed the drug off-label for weight loss, and still suffered from serious side effects

Its compact molecular architecture enables selective binding to the NNMT active site, allowing researchers to study dose-dependent enzyme inhibition in vitro and in preclinical models

Materials and methods: The study consists of individuals from the Ulm and LURIC cohorts, categorized into three main groups: HbA1c-only prediabetes (n=118 Ulm, n=539 LURIC), OGTT-only prediabetes (n=339 Ulm, n=200 LURIC), and concordant prediabetes (n=271 Ulm, n=338 LURIC)

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