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Patients should contact their GP or prescribing clinician if they experience any of the following: Severe or worsening fatigue that significantly impairs daily activities, work performance, or quality of life should be assessed

Picomolar A concentration unit equal to 10 molar

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The KBD area roughly coincides with low-selenium areas including a geological belt extending from northeast to southwest China, North Korea, and eastern Siberia 22

980,981 A Phase 3, multicenter, randomized trial (EudraCT 2012-000353-31, NCT01825512) compared the efficacy of DFX and DFP in pediatric patients with transfusion-dependent haemoglobinopathies and found that DFP was more effective and safer in controlling iron overload than DFX over a 12-month treatment period