Experimental data on animal models have suggested that GIP suppresses peripheral arterial remodeling, thus showing an anti-atherosclerotic activity, by acting on receptors in the heart and vessels." Outcomes of clinical trials The first clinical trial to test the clinical efficacy of TZP was the SURPASS program, a six-stage trial conducted on three separate cohorts Japanese (SURPASS-J), Asian-Pacific (SURPASS-AP), and the cardiovascular outcome trial (SURPASS-CVOT)
This protocol involved lower bioavailability but more convenient methods
[DOI] [PubMed] [Google Scholar] 48.Nguyen J, Remyn L, Chung IY, Honigman A, Gourani-Tehrani S, Wutami I, et al
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2014;42(3):301-317.doi:10.1124/dmd.113.055236 Yang P, Gu H, Zhao Z, et al.Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-inducedacute lung injury