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Clinically, elevated levels of endogenous GLP-1 have been observed in patients with sepsis (6.35-fold increase), end-stage renal disease (4.46-fold), and burns (2.96-fold), indicating a common physiological response to critical illness ( Despite these observations, exogenous GLP-1RAs appear to exert beneficial effects

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Meaningful results may not be apparent until 1216 weeks into treatment, particularly during the dose-escalation phase

392 Therefore, regulating the Th/Treg balance can significantly alleviate the intestinal inflammatory response and protect the intestinal barrier