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Eat smaller meals, more frequently

Individual results outside such a setting will vary based on starting point, dose, adherence, diet, activity, and many other factors

The effect is documented even in non-diabetics with overweight/obesity, a broader patient group than previously assumed

The reasonable reading is that cagrilintides gastrointestinal effects are mechanism-based and generally manageable with titration in the studied populations, but that manageable in trials is not the same as fully characterized for long-term real-world use, and the delayed-emptying mechanism itself carries context-specific cautions that should not be waved away

In the 1900s, Karl Herxheimer noted a similar reaction