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The Cu2+ ion is coordinated by the histidine imidazole nitrogen and the N-terminal amino group of glycine, forming a specific metal-peptide complex

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This novel link to epigenetic plasticity during epithelial-to-mesenchymal transition adds to previous studies showing a role for iron in metastatic ability likely through downregulation of N-myc downstream-regulated gene 1 (NDRG1) [16], a metastatic suppressor that is usually decreased in several types of cancer

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