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The successful engineering of IGF1 LR3 to overcome the limitations of native IGF-1 provides lessons applicable to the growth of other peptide-based therapeutics

doi: 10.1016/j.cub.2014.03.034 9 MassartCHosteCVirionARufJDumontJEVan SandeJ

Large-molecule biologics are not subject to the protein-displacement interactions that affect small molecules