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37 Additionally, a meta-analysis published in Gastroenterology concluded that split-dose regimens are more effective than day-before preparations, with 4-L split-dose PEG showing particularly high efficacy
Prescribing GLP-1s: Evidence, limits, expectations How physicians integrate GLP1s into long-term weight management GLP-1 medications are reshaping the conversation around metabolic health and weight loss but questions remain
Larger, multicenter trials with balanced cohorts and extended follow-up are required to confirm comparative effects on HbA1c sustainability, beta-cell preservation, and insulin sensitivity
While their high efficacy has led to a global surge in prescriptions, side effects such as the loss of muscle along with fat and nutritional imbalances are consistently reported in clinical settings with long-term use