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Shutze continues, including preclinical testing, multiple trials that evaluate the drugs safety and side effects when used for a particular indication, and a final evaluation based on the manufacturers application of what the drug is intended to treat. When the drug is approved for use by the FDA its authorized only for the indication(s) that are in the application

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In the past ten years, a series of Phase III trials showed that the synthetic GLP-1/GIP agonists are effective in lowering blood sugar in type 2 diabetic subjects who were both treatment-nave or on typical first-line therapies such as metformin and insulin

Many weight loss drugs had to be taken off the market because of cardiac valve disease, pulmonary hypertension, and other serious problems