Stopping the semaglutide 3 to 7 days prior to surgery was an independent risk factor for aspiration, while the 14-day and 30-day cohorts had no independent risk factor for this complication
This 4.3 percentage point difference is clinically meaningful and statistically significant
10.1126/sciimmunol.aar7754 [DOI] [PubMed] [Google Scholar] Fang Y., Ji L., Zhu C., Xiao Y., Zhang J., Lu J., et al
As mentioned, a secondary analysis of an RCT assessing the cardiometabolic effects of exenatide in 40 people with schizophrenia 140 also looked at measures of cognition and psychosocial functioning (that is, Brief Assessment of Cognition in Schizophrenia, ReyOsterreith Complex Figure Test, Short-Form Health Survey, Personal and Social Performance Scale, Positive and Negative Syndrome Scale), but found no effect for this GLP-1RA compared with placebo over 3 months 133
If you need to stop taking a GLP-1 medication whether due to cost, availability, or side effects gradually tapering off the medication may help minimize rebound hunger and weight regain