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A 2-week period where you increase calories to maintenance (not a free-for-all, just maintenance) can reset metabolic signaling

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When should I stop gliclazide (sulfonylurea) in a patient with controlled blood glucose levels on Ozempic (semaglutide), linagliptin (DPP-4 inhibitor), and metformin (biguanide)?

Clinical data supports extended use beyond 68 weeks, and many specialists recommend ongoing therapy to prevent weight regain

Brain-derived neurotrophic factor mechanisms and function in adult synaptic plasticity: new insights and implications for therapy