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Since the progression to invasive PDAC is believed to take more than a decade, the follow-up periods in many cohort studies and randomized controlled trials (where it is typically 12 years) are insufficient to understand the long-term effects

One of the most common causes of dry eye syndrome (keratoconjunctivitis sicca) is decreased tear production resulting from age, medical conditions (diabetes, rheumatoid arthritis, thyroid disorders), and certain medications

doi: 10.1371/journal.pone.0119034, 126 RichardsP.ParkerH

95% CI 0.38 0.99

Endoplasmic reticulum stress in pancreatic beta cells induces incretin desensitization and beta-cell dysfunction via ATF4-mediated PDE4D expression