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Continuous TVS activation might cause an ongoing discharge of CGRP

Common MCAS symptoms include: Skin flushing, itching, or hives Digestive upset, bloating, or diarrhea Fatigue and brain fog Anxiety or heart palpitations Headaches or light sensitivity MCAS can be triggered by underlying infections, mold exposure, chemical sensitivity, or immune dysfunction

This explains why it doesnt produce the dependence liability seen with benzodiazepines

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Metabolomic Analysis Identifies Altered Metabolic Pathways in Multiple Sclerosis