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Mechanistically, sunitinib, but not bevacizumab, suppressed HIF-1 required for endothelial differentiation under hypoxic conditions ( Non-VEGF Angiogenic Pathways in Breast Cancer The lack of efficacy of the conventional angiogenesis inhibitors necessitates exploring novel angiogenic pathways in breast cancer

In mouse models of Alzheimer's disease, systemic administration of GHK-Cu for 12 weeks results in 30% improvement in cognitive function tests and 25% reduction in brain amyloid plaque burden compared to vehicle-treated controls