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Inhibition of KEAP1 by RTA 408 disinhibits the antioxidant transcription factor nrf2 and has neuroprotective and seizure reducing effects in the kainic model of TLE (Shekh-Ahmad et al., 2018)

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These interventions showed high feasibility and moderate to high evidence strength, especially when applied to overweight or sedentary T2DM patients

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