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APAP hepatotoxicity occurs through formation of the noxious NAPQI metabolite, which is present in excessive quantities, as augmented by features of glutathione (GSH) depletion, oxidative stress and mitochondrial dysfunction leading to depletion in adenosine triphosphate (ATP) stores

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No significant differences were observed in the percent TBWL between monotherapy and combination therapy patients

Occasionally, some patients with hypothyroidism have no symptoms at all, or the symptoms are so subtle that they go unnoticed

The same dose of L-carnitine and selenium was used in the intervention group of this trial, while participants in both the intervention and control groups also received standard therapy (methimazole and beta blockers)