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A multicentre retrospective study of 499 patients identified ICI patients with renal cell carcinoma (RCC) in which 80 patients developed severe irAEs warranting treatment cessation, 36 of whom were able to be restarted on an ICI agent and 44 permanently discontinued

GLP-1Rs are highly expressed in the LS and their signaling has been shown to attenuate the locomotor response to the psychostimulant d-amphetamine, 1 to reduce cocaine CPP, 14, 16 and to block self-administration for cocaine in rodents

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However, there is increasing evidence that induction of ferroptosis can reverse tumor chemotherapy resistance (133)