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The small intestine houses IF receptors that bind B12 to create a complex, allowing it to be absorbed through the intestinal lining and into systemic circulation

Recently, Mazza and colleagues demonstrated bilirubins antioxidant and cytoprotective effects in relation to damage to endothelial cells mediated by angiotensin II (38)

Nature (2022) 604(7907):697+

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In a rat acute myocardial infarction model, created by ligating the anterior descending branch of the left coronary artery, catalpol inhibits myocardial cell necrosis and apoptosis by downregulating the receptor-interacting protein-1 (RIP1)/RIP3/MLKL pathway ( Catalpol also prevents cardiovascular toxicity induced by acute exposure to diesel exhaust particles by inhibiting NF-B activation (Nemmar et al., 2022)