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25 In the Rosenstock et al trial, retatrutide showed significant reductions in HbA1c and body weight in participants with T2DM

Comparison: Weight Loss Injections vs Weight Loss Surgery Weight loss injections are a non-surgical alternative

Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.The handling editor declared a past co-authorship with the authors

This paper will systematically evaluate the efficacy, safety, and mechanisms of tirzepatide in the treatment of type 2 diabetes and explore its potential in cardiovascular disease risk management, providing a new perspective on the comprehensive management of diabetes and its complications