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GPx1 The GPx1 gene, which encodes the first identified selenoprotein, is located on chromosome 3p21 [72, 73]

HIF-1 activates glycolysis-related genes, including pyruvate dehydrogenase kinase 1 (PDK1), increasing the conversion of glucose to pyruvate and subsequently to lactate by inactivating PDH, which is considered critical for metabolic adaptation to hypoxia [74] [Figure 1F]

It also explained when selenium supplements might make sense, which I discussed with my clinician

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